Thursday, March 1, 2012

Steroid Toxicities

Toxicities of Prednisone/Corticosteroids:

Don't have a clever way to remember this one, just kind of do...

"CHIP CHOPA"

Cushingoid Changes
Hypertension
Immunosuppression
Psychosis (steroid related)

Cataracts
Hyperglycemia
Osteoporosis
Peptic ulcers
Acne

They also say that Cortisol is BBIIG, which may help you remember its functions, and tie it in with toxicities:

Blood pressure increased
Bone formation decreased
Immunosupression
Inflammatory retardant
Gluconeogenesis, lipolysis, proteolysis

Not one of my favorite mnemonics but it does give you a hint at some of the toxicities.

Anion Gap Metabolic Acidosis

Many people use the good old MUDPILES mnemonic, but I found one that I like more, that's more inclusive:

"CUTE DIMPLES"

Cyanide
Uremia
Toluene
Ethanol

Diabetic Ketoacidosis
Isoniazid and Iron
Methanol
Propylene Glycol, Phenformin, Paraldehyde (the last 2 aren't really used anymore)
Lactic Acidosis
Ethylene Glycol
Salicylates